Professor Owusu served as Head of Department of Animal Biology and Conservation Science, from 2008 to 2010 and followed that with tenure as the Vice Dean of the Faculty of Science from 2010 to 2014.He also served as the Dean of the School of Biological Sciences from August to September in 2014 and Acting Dean, School of Biological Sciences from September, 2014 to June, 2015.
In 1998, Professor Owusu was appointed lecturer at the Department of Zoology, University of Ghana (now Animal Biology and Conservation Science).
He was promoted to Senior lecturer in September 2000 and then to Associate Professor and Professor in June 2005, and March 2010 respectively. He has mentored several students to obtain their MPhil and PhDs.
Outside the university of Ghana community, he served as Country Director of KANEMATSU Corporation, Tokyo, Japan (Ghana Office) from July, 2001 to December, 2004 and Country Manager, SIRUS Corporation, Tokyo, Japan from 2005 to 2009.
Professor Owusu is touted as a scholar of international repute with proven knowledge and experience in university administration and governance in addition to commendable fundraising ability.
In 1999, he was behind the building of a laboratory (Food Security) at the University of Ghana for use by staff and students.
He was also solely responsible for the acquisition and installation of a Scanning Electron Microscope worth US$500,000, the first of its kind in West Africa, through a grant from the Government of Japan.
Professor Owusu has served on numerous University Boards and Committees as well as serving as Hall Tutor of Jean Aka Nelson Hall, the University Teachers Association of Ghana (UTAG) Secretary as well as Editor-in-chief of the Journal of the Ghana Science Association, Regional Editor for the UNESCO African Journal of Science and Technology and a reviewer for a number of other international journals.
Professor Owusu is also member of the University of Cambridge African Research Partnership (CAPREx) team.
Professor Ebenezer Oduro Owusu is expected to assume the post of Vice Chancellor on August 1, 2016.
He shrugged off competition from other professors in the University to earn the nod as the man who will replace current Vice Chancellor Professor Ernest Aryeetey who leaves office in July.
The shortlist for the position of Vice Chancellor included Professor Samuel Agyei Mensah (Provost of the College of Humanities), Professor John Gyapong (Pro Vice Chancellor, Research and Innovation) and Professor Akosua Adomako Ampofo (Former Director of the Institute of African Studies).